Heterozygous vs. Homozygous: What’s the Difference? — Passage

Grades
5
6
7
8
Standards
MS-LS3-1
MS-LS3-2
PRINT+DIGITAL RESOURCE
This learning resource is available in interactive and printable formats. The interactive worksshet can be played online and assigned to students. The Printable PDF version can be downloaded and printed for completion by hand.
ABOUT THIS READER
This NGSS-aligned middle school passage explains the difference between heterozygous and homozygous allele combinations. Students will learn that homozygous individuals have two identical alleles, while heterozygous individuals have two different ones. The passage uses clear examples (like BB, bb, and Bb) and explains how dominant and recessive alleles interact. It also introduces Punnett squares to predict inheritance patterns and discusses real-world applications in medicine and agriculture. Key terms like dominant, recessive, genotype, and heredity are clearly defined. This passage supports reading comprehension and meets NGSS standard MS-LS3-1 (Heredity: Inheritance and Variation of Traits).
Publisher: Workybooks
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Written by:Workybooks Team
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Illustrated by:

In genetics, the terms heterozygous and homozygous describe the combinations of alleles an organism inherits from its parents. Alleles are different forms of the same gene, and they determine an organism’s traits, like eye color or blood type. Each person gets one allele from each parent, forming a pair for every gene.

 

A person is homozygous if the two alleles for a gene are the same. These can be homozygous dominant (like BB) or homozygous recessive (like bb). In both cases, the same version of the gene is inherited from each parent. If the gene is dominant, the trait will be visible even with just one copy. If the gene is recessive, the trait only appears when both alleles are recessive.

 

A person is heterozygous if the two alleles are different, such as Bb. In this case, the dominant allele will mask the recessive allele, so the dominant trait is the one that shows up. Even though the recessive gene is present, it doesn’t affect the outward trait unless paired with another recessive allele.

 

Scientists use Punnett squares to predict whether offspring will be homozygous or heterozygous for a trait. For example, if one parent has two dominant alleles (BB) and the other has two recessive alleles (bb), all their children will be heterozygous (Bb). This kind of inheritance explains why traits sometimes “skip” a generation.

 

Understanding the difference between heterozygous and homozygous is important in genetics, medicine, and breeding. Some genetic disorders only occur in homozygous individuals. In farming, breeders choose between homozygous and heterozygous plants and animals to get the traits they want.

 

Fun Fact: Pea plants were the first organisms used to study heterozygous and homozygous traits—by a monk named Gregor Mendel in the 1800s!

 

What do heterozygous and homozygous describe?

Types of cellsBody systemsCombinations of allelesTypes of traits

What does homozygous mean?

Two different allelesOne allele onlyTwo identical allelesNo alleles present

Which is a heterozygous genotype?

BBBbbbBBbb

What kind of allele is masked in a heterozygous pair?

DominantInheritedRecessiveNeutral

What will all offspring be if one parent is BB and the other is bb?

bbBBBbbB or BB

Why can a recessive trait “skip” a generation?

It is forgottenIt needs two recessive allelesIt’s weakerIt disappears randomly

What is the main idea of the passage?

Heterozygous traits are rareAlleles are always recessiveDominant traits are unhealthyHeterozygous and homozygous describe allele pairs

How is this knowledge used in farming?

To grow only recessive plantsTo stop traits from changingTo select traits in plants and animalsTo change the color of crops

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